This is third edition of Tim Benson’s now standard text on healthcare interoperability. It does focus on the specific technologies listed in the title, but it’s more than just a handbook. Instead, it begins with a careful discussion of interoperability, and why building interoperable solutions in the healthcare domain has proven so difficult. The analysis is insightful, and well worth reading for any healthcare professional, informatics, or developer. The book offers no magic bullets, but understanding the nature of the problem is key developing solutions.